View the ANEclear in-service video
When general inhaled anesthesia is administered, anesthetics in the form of vapors are delivered to a patient in .5% to 10% concentrations, depending on the anesthetic agent used. As the individual inhales an anesthetic vapor, the vapor enters the lungs, moves into the bloodstream and is carried by the blood to the brain. Once the surgical procedure has been completed, the process is reversed. Blood carries the anesthetic from the brain to the lungs where it is exhaled from the body. The time it takes for a patient to awaken after general anesthesia depends on the time it takes to remove the anesthetic from the brain. The concentration of anesthetic in the patient’s brain needs to decrease to the level at which consciousness returns. The higher the brain blood flow and the ventilation rate, the quicker the effects of the general anesthetic are reversed and the quicker the patient wakes up.
Time to emergence from inhaled volatile anesthesia is limited by the time required to remove anesthetic gases from the lungs, and the time required to carry anesthetic agents from the brain via the blood stream to the lungs. The classic approach to accelerating the clearance of anesthetic gasses from the lungs is to artificially raise ventilation. Raising ventilation lowers alveolar carbon dioxide partial pressure and thus arterial carbon dioxide partial pressure. This has the undesired effect of lowering blood flow to the brain and delaying emergence from anesthesia.
Herein lies the problem; increased ventilation will speed removal of anesthetic from the lungs and arterial blood; however, increased ventilation will also decrease blood flow to the brain. Decreased ventilation will allow increased blood flow to the brain, but the concentration of anesthetic in the blood will remain high, thereby eliminating the benefit of higher brain blood flow.
Anecare has created the ANEclear, a unique patent-pending disposable device that allows the effect of increased ventilation to work without lowering blood CO2 concentration which leads to lower blood flow to the brain. When the device is activated in the anesthesia breathing circuit, the fraction of inspired agent is essentially zero and patient ventilation can be increased without an undesirable decrease in blood flow to the brain.
By creating this state of mild hypercapnia combined with hyperventilation, the ANEclear actively eliminates anesthetic from the patient and increases spontaneous respiration. The result is a patient who can be extubated sooner and who is more awake at extubation in the OR.
Further, the ANEclear continues to accelerate spontaneous respiration following extubation, which means patients are more alert and conscious in the PACU and can participate in pain assessment and management. This translates into improved patient safety, satisfaction and a shorter PACU stay.